Gelatin Melting Process in Soft Capsule Production

CELINE PHARMA

Gelatin Melting Process in Soft Capsule Production

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In soft capsule manufacturing, the gelatin melting process is a critical step. Typically, gelatin powder and plasticizers are added to a melting reactor and mixed under agitation at 60–95°C to fully dissolve the gelatin. The melting conditions depend on the capsule shell formulation and the gelatin’s gel point, which correlates with its mechanical/thermal properties.

The water-to-dry-gelatin ratio (0.7–1.3 w/w) is adjusted based on the gelatin source’s viscosity. After complete melting, additional ingredients (e.g., opacifiers, colorants, preservatives) can be directly introduced into the reactor or pre-mixed with plasticizers. Note that opacifiers often require extended mixing (e.g., in rotating drums), while other components may need high-speed dispersion.

The gelatin mixture is then homogenized under vacuum, followed by filtration to remove undissolved polymers. The final gelatin solution is stored in temperature-controlled tanks (57–60°C) until encapsulation.

Key Considerations:

  • Physical properties (viscosity, flowability, tackiness) are vital for capsule formation, especially when using rotary die or plate molding.
  • Thermal sensitivity: Gelatin is a "live" material—prolonged heat exposure can cause depolymerization, reducing gel strength and viscosity over time.

This controlled process ensures consistent gelatin ribbons for high-quality soft capsules.

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